Lilly drug chosen for Alzheimer's prevention study

Researchers have chosen an experimental drug by Eli Lilly & Co. for a large federally funded study testing whether it's possible to prevent Alzheimer's disease in older people at high risk of developing it.

The drug, called solanezumab (sol-ah-NAYZ-uh-mab), is designed to bind to and help clear the sticky deposits that clog patients' brains.

Earlier studies found it did not help people with moderate to severe Alzheimer's but it showed some promise against milder disease. Researchers think it might work better if given before symptoms start.

"The hope is we can catch people before they decline," which can come 10 years or more after plaques first show up in the brain, said Dr. Reisa Sperling, director of the Alzheimer's center at Brigham and Women's Hospital in Boston.

She will help lead the new study, which will involve 1,000 people ages 70 to 85 whose brain scans show plaque buildup but who do not yet have any symptoms of dementia. They will get monthly infusions of solanezumab or a dummy drug for three years. The main goal will be slowing the rate of cognitive decline. The study will be done at 50 sites in the U.S. and possibly more in Canada, Australia and Europe, Sperling said.

In October, researchers said combined results from two studies of solanezumab suggested it might modestly slow mental decline, especially in patients with mild disease. Taken separately, the studies missed their main goals of significantly slowing the mind-robbing disease or improving activities of daily living.

Those results were not considered good enough to win the drug approval. So in December, Lilly said it would start another large study of it this year to try to confirm the hopeful results seen patients with mild disease. That is separate from the federal study Sperling will head.

About 35 million people worldwide have dementia, and Alzheimer's is the most common type. In the U.S., about 5 million have Alzheimer's. Current medicines such as Aricept and Namenda just temporarily ease symptoms. There is no known cure.

___

Online:

Alzheimer's info: http://www.alzheimers.gov

Alzheimer's Association: http://www.alz.org

___

Follow Marilynn Marchione's coverage at http://twitter.com/MMarchioneAP

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Teacher who starred in porn film fight for job, money

The
Oxnard teacher who was fired for appearing in porn movies has until Feb. 13 to decide
whether to appeal a decision dismissing her from the classroom, school officials said.

The
Commission on Professional Competence, in a 47-page report dated Jan. 3, found that Stacie Halas, 32, was unfit to
teach eighth-grade science at Haydock Intermediate School and ordered her
dismissal.

Although Halas filmed the scenes between 2005 and 2006, before she was employed at the middle school, the ongoing availability of the videos will continue to hamper her ability to be an effective teacher, Judge Julie Cabos-Owen wrote.

Halas
can appeal the dismissal order to Ventura County Superior Court, her attorney Richard Schwab told The Times. He didn’t know if Halas would ask
for an appeal.

On
Wednesday, the Oxnard School District Board of Trustees moved to terminate her
administrative pay as of Feb. 13. The board fired Halas in April after students
discovered her pornographic films.

Halas
then appealed the board’s decision to the Commission on Professional Competence, which ruled against her.

That’s
“the last day for her to file an appeal in Superior Court, which runs for 30
days from the ruling,” said Tom DeLapp, school district spokesman.

“We have no
indication whether she will pursue this option.”

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-- Adolfo Flores

Photo: Stacie Halas. Credit: KTLA

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As Rescue Operation Continues in Algeria, Fate of Hostages Remains Unclear

British Petroleum, via European Pressphoto Agency

The remote In Amenas natural gas field in Algeria, the site of a terrorist attack and the taking of hostages on Wednesday.

BAMAKO, Mali — Dozens of foreign hostages may still be held by Islamist extremists who have defied demands to surrender in a besieged Algerian gas-field complex, Algeria’s state-run news agency reported Friday, and the United States said for the first time that American citizens were among them.

Twelve Algerian and foreign workers have been killed since Algerian special forces began an assault against the kidnappers, the state news agency reported, citing an unnamed security official. It was the highest civilian death toll Algerian officials have provided in the aftermath of the assault, which freed captives and killed kidnappers but also left some hostages dead.

Previous estimates of the foreign casualties have ranged from 4 to 35.

The Algerian news agency said that the country’s special forces were still seeking to reach a “peaceful solution” with the remnants of a “terrorist group” that was still holding hostages in the refinery area of the gas field in remote eastern Algeria. It also gave a new sense of how many people may have been at the facility when the militants seized it on Wednesday, asserting that nearly 650 had managed to leave the site since then, including 573 Algerians and most of the 132 foreigners it said had been abducted.

But that still left many people unaccounted for, adding to the global concern about the fate of the hostages, who come from as many as 10 different nations.

In Washington, the State Department spokeswoman, Victoria Nuland, said that not all Americans had been freed and that Secretary of State Hillary Rodham Clinton had spoken for the third consecutive day by telephone with top Algerian leaders about American concerns for their safety.

“We have American hostages,” Ms. Nuland told reporters, offering the government’s first update on what is known about the Americans since officials confirmed on Thursday that seven or eight Americans had been inside the gas-field complex.

Ms. Nuland also said the United States would not consider a reported offer made by the kidnappers to exchange two Americans for two prominent figures imprisoned in the United States — Omar Abdel Rahman, a sheik convicted of plotting to bomb New York landmarks, and Aafia Siddiqui, a Pakistani woman convicted of shooting two American soldiers in Afghanistan. It was impossible to confirm that offer, which was reported by the Washington-based SITE Intelligence Group, a service that tracks jihadist activity on the Internet.

Intensifying the uncertainties, a spokesman for the militants, who belong to a group called Al Mulathameen, said Friday that they planned further attacks in Algeria, according to a report by the Mauritanian news agency ANI, which maintains frequent contact with militant groups in the region. The spokesman called upon Algerians to “keep away from the installations of foreign companies, because we will suddenly attack where no one would expect it,” ANI reported.

A Pentagon official said an Air Force C-130 had left Algeria for an unidentified base in Europe, carrying a number of the rescued hostages but no Americans. The official said a second, larger evacuation plane, a C-17, was still on the ground in Algeria, and it was unclear how many rescued hostages would be boarded or when it would depart.

A separate hostage situation of sorts appeared to be evolving at a village in Mali, the neighboring country where a French military intervention to stop radical Islamists may have been the catalyst for the Algerian gas-field seizure by the Al Mulathameen group.

A senior French official in Paris said Malian Islamist fighters, threatened by French and Malian soldiers, had occupied the village, Diabaly, and were threatening to use residents as human shields if attacked.

“We do not want a blood bath,” the French official said, and the troop commanders had chosen not to engage so far in house-to-house fighting.

The Algerian military operation at the gas field began on Thursday without consultation with the foreign governments whose citizens worked at the gas field facility. It has been marked by a fog of conflicting reports, compounded by the remoteness of the facility, near a town called In Amenas hundreds of miles across the desert from the Algerian capital, Algiers, and close to the Libyan border.

Algeria’s state radio, citing an official source, reported on Friday that 18 militants had been killed, the first precise death count offered by state media. The state news agency also suggested that hundreds of civilians “had been freed,” though many of the employees inside the sprawling facility may have simply been on site at the time of the militant assault and were not necessarily being held by the kidnappers.

Adam Nossiter reported from Bamako and Alan Cowell and Scott Sayare from Paris. Reporting was contributed by Rick Gladstone from New York; Elisabeth Bumiller, Julia Werdigier and John F. Burns from London; Steven Erlanger from Paris, Eric Schmitt, Thom Shanker, David E. Sanger and Michael R. Gordon from Washington; Martin Fackler and Hiroko Tabuchi from Tokyo; and Mayy El Sheikh from Cairo.

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With an air kiss or empty hug, Te’oing is Twitter craze

NEW YORK (Reuters) – Manti Te’o, the Notre Dame linebacker entangled in a girlfriend hoax that gives a whole new meaning to the term “air kiss,” is inspiring a new fad racing through social media: Te’oing.

An avalanche of pictures of people hugging empty chairs or puckering up to an otherwise empty room were posted to Twitter with the hashtag #Te’oing days after the college football star’s story about his girlfriend’s cancer death was exposed as a fraud. Not only did she never have leukemia, she never existed.

Notre Dame officials said Te’o told them he had been duped into believing he had an online relationship with the fictitious woman.

“Te’oing – Mile High Club edition” read one tweet with a photo of a man hugging the air in an airplane bathroom, an apparent reference to the whispered practice of having sex in mid-flight.

Clint Eastwood was hailed in several tweets as a “Te’oing” pioneer for the actor’s interlude with an empty chair at the 2012 Republican Convention. Other tweets showed Ronald McDonald Te’oing on his cozy bench and President Barack Obama spending quality time Te’oing with a vacant seat.

“Just some afternoon bubbly with my baby” said one Te’oing tweet with a photo of a man clinking his champagne flute against another that appeared to be suspended in mid-air.

The snarky social media frenzy recalled another similar trend called the “Tebowing,” named for New York Jets quarterback Tim Tebow, who frequently kneeled for on-field prayers and inspired copy-cat poses by people whose pictures flooded social media last year.

In its own riff on emptiness and romance, a Kentucky minor league baseball team, the Florence Freedom, has announced it will give away Manti Te’o Girlfriend Bobblehead dolls – actually empty boxes – to the first 1,000 fans at the May 23 game.

One section of the Florence, Kentucky, stadium has been reserved “for fans to sit with their imaginary friends, girlfriends/boyfriends or spouses” who may be caught on the “pretend kiss cam” and are invited to compete in an air guitar contest or an imaginary food fight.

(Writing by Barbara Goldberg; Editing by Paul Thomasch and Vicki Allen)

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Channing Tatum & Jenna Dewan-Tatum Share a Fresh, Healthy Lunch Date

Caught in the Act

01/18/2013 at 01:35 PM EST

Jenna Dewan-Tatum and Channing Tatum

FameFlynet

Eating for three!

Parents-to-be Jenna Dewan-Tatum and husband Channing, fresh from a beach holiday in St. Barts, enjoyed a casual lunch date together on Wednesday.

The couple, who wed in 2009 and announced their happy baby news in mid-December, shared their meal at Greenleaf Gourmet Chopshop in Beverly Hills.

Jenna, 32, went with healthy eating, dining on the restaurant's seasonal salad (kale, tangerine, dried blueberry, almonds and citrus vinagrette) while PEOPLE's Sexiest Man Alive, also 32 – and an Alabama native – chose more hearty Southern fare, specifically a barbecue chicken sandwich.

"They were a sweet couple and she's got a little bump too," said an onlooker.
– Jennifer Garcia

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Man molested girls, gave them tattoos, police allege

Authorities were looking Thursday for more possible victims of a Mission Viejo tattoo artist arrested for allegedly molesting two teenage girls after giving them free tattoos and alcohol in his apartment, deputies said.

Edder Giovani Nieves-Vera, 29, met one of the 14-year-olds through Facebook and promised to give her a tattoo, alcohol and drugs, said Jim Amormino, a spokesman for the Orange County Sheriff’s Department.

In December, authorities believe the girl and a 14-year-old friend went to the man’s apartment, where he supplied them with alcohol and gave them tattoos.

He is suspected of making “sexual advances” toward the teenagers and engaging in “highly inappropriate conduct,” Amormino told the Times.

The girls told authorities, who then posed as one of the 14-year-olds by chatting with him on Facebook, said Gail Krause, a spokeswoman with the Sheriff’s Department.

Nieves-Vera allegedly said he wanted to meet the girl Tuesday at Dana Point Harbor, then take her to his apartment to finish the tattoo and enjoy his Jacuzzi. Instead, Nieves-Vera was met by investigators and taken into custody.

Several years ago, he was deported after serving three years in state prison in connection with a 2004 arrest in a child annoyance case in Riverside County. Investigators do not know when Nieves-Vera re-entered the United States.

The Sheriff’s Department, along with several other agencies, including the Orange County district attorney’s office, the FBI and the U.S. Postal Inspection Service, investigated the case.

Anyone with information is asked to call the Sheriff’s Department at (714) 647-7000. Anonymous tippers may call OC Crime Stoppers at (855) TIP-OCCS.

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Reward offered for 'AK-47 Bandit' who shot Chino officer

Robert Citron, treasurer at center of O.C. bankruptcy, dies

Environmental group pushes for hearing on San Onofre restart

-- Robert J. Lopez and Nicole Santa Cruz

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Algeria Confirms Hostage Deaths in Rescue Raid

BAMAKO, Mali — Kidnappers and at least some of their hostages were killed on Thursday as Algerian forces assaulted a heavily armed group of Islamist extremists holding dozens of captives, including Americans and other foreigners, in a remote gas field facility in the Algerian desert, the Algerian government announced.

Kjetil Alsvik/Statoil, via Agence France-Presse — Getty Images

An undated photo of the In Amenas gas field in Algeria, where Islamist militants took dozens of foreign hostages on Wednesday.

In a statement on national radio, the communications minister, Mohand Saïd Oublaïd, said that many of the hostages had been freed, but he warned that the military assault was not yet complete and that some captives remained trapped inside the facility.

“The operation resulted in the neutralization of a large number of terrorists and the liberation of a considerable number of hostages,” Mr. Oublaïd said. “Unfortunately, we deplore also the death of some, as well as some who were wounded. We do not have final numbers.”

He also said “the operation is ongoing, given the complexity of the site, to liberate the rest of the hostages and those who are trapped inside.”

The announcement was the most detailed official information given by Algeria on the crisis. It began more than 24 hours earlier when Islamist militants seized the hostages at the internationally managed gas field in the Sahara near the Libyan border, in what they called retaliation for the French military intervention in neighboring Mali. The seizure of the gas field was one of the boldest abductions of foreign workers in recent years.

Unconfirmed news reports earlier on Thursday, quoting a statement reportedly from the hostage takers, said the Algerian military assault had left 35 hostages and 15 kidnappers dead. One Algerian government official called those numbers “exaggerated.”

The communications minister said the military assault force sent to end the gas-field siege had first sought a peaceful end.

“But confronted with the determination of the heavily armed terrorist group, our armed forces were forced to surround the site and fire warning shots,” he said. “In front of the stubborn refusal of these terrorists to heed these warnings and confronted with their evident desire to leave Algeria with the foreign hostages to then use them as a bargaining chip, an assault was launched this Thursday at the end of the morning.”

The minister’s announcement came as foreign governments, including the United States, were seeking clarity on the fate of their citizens trapped inside the gas-field facility. There was no sign that the Algerians had given prior notice to any of the countries whose citizens were among the hostages.

A senior American official said Pentagon aides traveling in London with Defense Secretary Leon E. Panetta were struggling to obtain basic information about the Algerian raid, and there were unconfirmed reports that an American Predator drone was monitoring the gas-field site.

The senior official said that perhaps seven to eight Americans were among the hostages — the first official confirmation of the number of Americans held captive — and that he did not know if any had been killed in the rescue operation.

David Cameron, the prime minister of Britain, said through a spokesman that his office had not been told ahead of time, an implicit criticism of the Algerian government. “The Algerians are aware that we would have preferred to have been consulted in advance,” the spokesman said.

Japan expressed even stronger concern, saying Algeria had not only failed to advise of the operation ahead of time, but that Japan had also asked Algeria to halt the operation because it was endangering the hostages.

“We asked Algeria to put human lives first and asked Algeria to strictly refrain,” the chief Cabinet secretary, Yoshihide Suga, quoted Prime Minister Shinzo Abe as telling his Algerian counterpart, Abdelmalek Sellal, by telephone late Thursday.

The situation is “very confused,” President François Hollande of France said at a news conference in Paris and was “evolving hour by hour.” Mr. Hollande confirmed for the first time officially that French citizens were among the captives.

The kidnapping in Algeria was a retaliation for the continuing French military assault on Islamist extremists in Mali that has escalated into a much broader conflict, now enmeshing the United States and other countries with citizens held hostage. Reuters said the survivors of the Algerian assault included hostages from the United States, Belgium, Japan and Britain. The full extent of the casualties was not immediately clear.

News agencies in Algeria and neighboring Mauritania said the helicopters may have attacked when the kidnappers sought to move their hostages from one part of the installation to another.

Adam Nossiter reported from Bamako, and Alan Cowell and Scott Sayare from Paris. Reporting was contributed by Clifford Krauss from Houston, Rick Gladstone from New York, Elisabeth Bumiller and John F. Burns from London, Steven Erlanger from Paris, Hiroko Tabuchi from Tokyo and Clifford Krauss from Houston.

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Amazon holiday results to show sales tax impact

SAN FRANCISCO (Reuters) – Acting as a tax collector may have hurt Amazon.com, Inc’s holiday sales analysts and industry executives said, but they expect to know more when the internet retailer reports its fourth-quarter results on January 29.

Best Buy Co., an archrival of Amazon in consumer electronics, saw holiday online sales increase in three states where Amazon started collecting sales tax ahead of the period.

“There was a little softness in states where Amazon is now collecting sales tax,” said R.J. Hottovy, an equity analyst at Morningstar. “That isn’t surprising to me. It levels the playing field for brick-and-mortar retailers.”

Critics of Amazon argued it had an unfair advantage because most retailers have had to collect state sales tax on online sales for years because they have stores and other physical operations in these locations.

But many states, hungry for extra tax revenue in the wake of the 2008 financial crisis, introduced new laws requiring that Internet-only retailers also collect sales tax. Brick-and-mortar retailers hope the requirement will reduce Amazon’s price advantage and help them recoup lost sales.

CHANNELADVISOR DATA

Amazon, the world’s biggest Internet retailer, began collecting sales tax of 7.25 percent to 9.75 percent in California on Sept 15, about two weeks before the start of the fourth-quarter. Third-party sellers on Amazon.com saw a drop in sales during the quarter, compared to other states, according to an analysis by e-commerce firm ChannelAdvisor.

It also started collecting sales tax in Pennsylvania in September and in Texas in July.

Amazon’s fourth-quarter results should provide clues on whether consumers changed their shopping habits when faced with higher taxes on their purchases from the company’s website.

ChannelAdvisor, which helps merchants sell more online, analyzed its clients’ sales on Amazon.com in California, and compared them to other states before and after the sales tax kicked in.

Before Amazon began collecting the tax in California, ChannelAdvisor client sales were 5 percent to 10 percent above other states. The week before the September 15 start of the tax, sales spiked as high as 70 percent compared to other states.

“The surge before the tax went into effect was much larger than I thought it would be,” said Scot Wingo, chief executive of ChannelAdvisor. “Californians definitely bought a lot in the three or four days before the tax went into effect.”

After Amazon began collecting tax, its California sales leveled with other states. Then, in early November, they slipped as much as 10 percent below other states, ChannelAdvisor data showed.

During one of the busiest holiday periods, in late November and early December, sales dipped further in California vs other states. Toward the end of the holiday period, client sales in California recovered, the data showed.

“There was a sales impact of about 10 percent at the worst point of the dip,” Wingo said. EBay, another Amazon rival, is an investor in ChannelAdvisor. Wingo also owned Amazon shares, but sold them in the fourth quarter for personal tax-related reasons.

Amazon’s tax collection in California had the most impact on fourth-quarter sales of more expensive items priced at $ 200 to $ 250, Wingo said.

PRICES, PROFIT

Amazon probably lowered prices by 8 percent to 9 percent on items most affected by this, although it is tricky to separate such reductions from the usual holiday season promotions that were also happening, Wingo said.

The extra price competition may dent Amazon’s profitability in the fourth quarter, Morningstar’s Hottovy said.

Amazon is expected to make 52 cents a share in the fourth quarter, on revenue of $ 22.3 billion, according to Thomson Reuters I/B/E/S. In late October, the company forecast operating results ranging from a profit of $ 310 million to a loss of $ 490 million.

Hottovy expects $ 22.4 billion in revenue and an operating loss of $ 210 million, or a $ 135 million loss after excluding stock-based compensation and other operating expenses.

BEST BUY

In California, Texas and Pennsylvania, Best Buy said it saw a 4 percent to 6 percent increase in online sales during the holiday versus the rest of its chain.

The retailer also saw an increase of 6 percent to 9 percent in online orders that are picked up in its stores in those three states compared with the rest of its chain.

Overall, Best Buy reported better-than-expected holiday sales last week, sending its shares up more than 10 percent.

“This makes Amazon equal to everyone else. They no longer have that sales tax advantage,” said Anne Zybowski, vice president of retail insights at Kantar Retail. “If this had happened to Amazon when they were just a bookseller years ago, they may not be as big as they are now.

Despite the tax changes, Amazon’s consumer electronics prices were still at least 5 percent below Best Buy’s during the holiday season, Zybowski said. But Best Buy may have benefited from even a small change in this area.

“Particularly in consumer electronics, any narrowing of Amazon’s price advantage at the margin is important because Best Buy brings service and other shopper benefits to the category,” she said.

Best Buy will take away people’s old TVs when they buy a new one and the company’s Geek Squad service will install devices in shoppers’ homes, services Amazon does not provide, she noted.

An Amazon spokesman declined to comment when asked if the company saw an impact on fourth-quarter sales from the collection of sales taxes in the three states.

In the past, Amazon executives have said there was little or no impact from such changes in other regions.

Several analysts have argued that shoppers use Amazon for its vast product selection and convenient, fast shipping and returns, and not just its low prices.

“While not great for Amazon, it’s just one of many consumer benefits its service offers,” said Ken Sena, an analyst at Evercore Partners. “And while there may be early effects from this change, I still see usage trends remaining in Amazon’s favor.”

(Editing by Leslie Gevirtz)

Tech News Headlines – Yahoo! News

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Holly Madison Is Ready to Get Daughter's Nursery Started

Mom & Babies
Celebrity Baby Blog

01/17/2013 at 01:00 PM ET

AKM-GSI

As usual, Holly Madison was all smiles on Wednesday. But don’t let her look deceive you — due in seven weeks, the former E! star is feeling a bit petulant.

Though she’s been preparing for the arrival of her daughter, Madison tells PEOPLE at the grand opening of Andrea’s at the Wynn in Las Vegas that she’s “stressing out because I’m supposed to be moving.”

“I need to get the nursery together, so I’m getting really impatient,” she explains.

“It’s going to be Alice In Wonderland-themed and I’m painting all these big murals so you feel like Alice when you walk in — all the tall flowers and all the caterpillar leaves. It’s going to take days to do it.”

Following a dispute about her doghouse with her current homeowners association, Madison, 33, is hoping to be settled in her new home sooner rather than later.

“I’m so antsy to get it done because I feel like the baby is going to come before I get a chance to get in there,” she says. “I’m supposed to be due the first week of March but she’s just going to come whenever she wants to come, so I don’t pay attention to that. I’m ready anytime.”

Luckily, the pregnancy has been smooth sailing overall, and Madison only craves fruit juices.

“I’m eating healthier than I normally would,” she notes. “I’ve been really lucky and feeling good. No problems.”

– Mark Gray

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Study: NYC better than LA at cutting kids' obesity

NEW YORK (AP) — A new study shows New York City is doing better than Los Angeles in the battle against childhood obesity, at least for low-income children.

From 2003 to 2011, obesity rates for poor children dropped in New York to around 16 percent. But they rose in Los Angeles and ended at about 20 percent.

The researchers focused on children ages 3 and 4 enrolled in a government program that provides food and other services to women and their young children.

The Centers for Disease Control and Prevention released the study Thursday.

The authors noted that the Los Angeles program has many more Mexican-American kids. Obesity is more common in Mexican-American boys than in white or black kids.

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